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Updated: Jul 28, 2026

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
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Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation

M Salatino1, W Beguelin, M G Peters

  • 1Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.

Oncogene
|June 27, 2006
PubMed
Summary

Progestin (MPA) upregulates caveolin-1 expression in breast cancer cells, promoting tumor growth. Inhibiting caveolin-1 reduces proliferation and progesterone receptor activity, identifying it as a key therapeutic target.

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