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Updated: Aug 7, 2026

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
Published on: March 24, 2015
HLA class II polymorphism: protective or risk factors to breast cancer in Tunisia?
Amal Baccar Harrath1, Besma Yacoubi Loueslati, Wafa Troudi
1Laboratory of Molecular Genetics, Immunology and Biotechnology, Faculty of Sciences of Tunis, ElManar University, Tunis, 1060, Tunisia. amal.baccar@laposte.net
Abstract:
HLA system plays a key role in the tumor cells' escape from immune surveillance. Herein is the first report on the correlation of the susceptibility to breast cancer with HLA class II markers in Tunisia. Molecular typing of HLA-DRB1 and -DQB1 loci was undertaken for 70 Tunisian female patients. Comparison of allele and haplotype distribution between patients and 70 female control subjects reveals a negative association between HLADRB1* 07-DQB1*02 and the incidence of breast cancer in the Tunisian population.
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