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Electrospinning of hexanoyl chitosan/polylactide blends.

Manisara Peesan¹, Ratana Rujiravanit, Pitt Supaphol

¹Technological Center for Electrospun Fibers, Chulalongkorn University, Soi Chula 12, Phyathai Road, Pathumwan, Bangkok 10330, Thailand.

Journal of Biomaterials Science. Polymer Edition

|June 28, 2006

Summary

Electrospinning hexanoyl chitosan (H-chitosan) and polylactide (PLA) blends yielded continuous fibers in chloroform but beaded fibers in dichloromethane. Fiber diameter decreased with higher H-chitosan content, impacting morphology.

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Area of Science:

Materials Science
Polymer Chemistry
Biomaterials Engineering

Background:

Chitosan derivatives offer tunable properties for advanced materials.
Polylactide (PLA) is a biodegradable polymer with diverse applications.
Electrospinning enables the fabrication of nano- and microfibers for various uses.

Purpose of the Study:

To investigate the electrospinning of hexanoyl chitosan (H-chitosan) and polylactide (PLA) blends.
To evaluate the effect of solvents and blend composition on fiber morphology and properties.
To characterize the thermal and structural properties of the resulting fibers.

Main Methods:

Electrospinning of H-chitosan, PLA, and their blends using chloroform, dichloromethane, or tetrahydrofuran.
Morphological analysis of as-spun fibers (surface and cross-section).

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Thermal analysis (Thermogravimetric Analysis, Differential Scanning Calorimetry) and Wide-Angle X-ray Diffraction (WAXD).

Main Results:

PLA fibers were round with rough surfaces; H-chitosan fibers were flat with smooth surfaces.
Continuous H-chitosan/PLA fibers were achieved in chloroform (≤50% H-chitosan); dichloromethane yielded beaded fibers.
Fiber diameter decreased with increasing H-chitosan content in blends (≤50% H-chitosan).

Conclusions:

Solvent choice critically influences H-chitosan/PLA blend electrospinning outcomes.
Controlled fiber morphology and diameter are achievable by adjusting blend composition and solvent.
The study provides insights into fabricating functional H-chitosan/PLA composite fibers.