Related Experiment Video
Updated: Aug 4, 2026

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells
Published on: October 23, 2018
The introduction of halothane into clinical practice: the Oxford experience
1Department of Anaesthetics, The Prince of Wales Hospital, Sydney, New South Wales, Australia.
Abstract:
This paper reviews the clinical situation in anaesthesia before the introduction of halothane into clinical practice in 1956, emphasising the limitations of agents available at the time. The background to the development of halogenated hydrocarbon compounds as anaesthesia agents is presented, including the involvement of Imperial Chemical Industries in England. The Nuffield Department of Anaesthetics was involved in the clinical trials and the designing and execution of these. The results of their work and the problems encountered are presented.
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