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Published on: June 28, 2021
Saw palmetto-induced pancreatitis
Ismaila Jibrin1, Ayodele Erinle, Abdulfattah Saidi
1St. Agnes Healthcare, 900 South Caton Avenue, Baltimore, MD 21229, USA. imjibrin@yahoo.com
Saw palmetto, a supplement for benign prostatic enlargement (BPH), may cause acute pancreatitis and hepatitis. This case highlights the potential risks of "natural" supplements and the need for thorough medication history.
Area of Science:
- Hepatology
- Gastroenterology
- Clinical Toxicology
Background:
- Saw palmetto is widely used for benign prostatic enlargement (BPH).
- While known to cause cholestatic hepatitis, its role in acute pancreatitis is not established.
- Patient is a 55-year-old male with a history of BPH and prior alcohol abuse.
Observation:
- The patient presented with severe epigastric pain, nausea, and vomiting.
- Laboratory results revealed elevated amylase, lipase, liver enzymes (AST, ALT), and triglycerides.
- Imaging showed sludge but no gallstones; a HIDA scan was negative.
Findings:
- A probable association between Saw palmetto use and acute hepatitis and pancreatitis was observed.
- The patient's symptoms resolved upon Saw palmetto withdrawal and recurred upon reintroduction.
- This cyclical pattern strongly suggests a drug-induced effect.
Implications:
- "Natural" supplements, including Saw palmetto, can pose significant health risks.
- Accurate and comprehensive medication histories, including supplements, are crucial for diagnosis.
- Further investigation into the hepatotoxic and pancreatotoxic potential of Saw palmetto is warranted.
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