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Design and synthesis of novel chemokine analogs derived from vMIP-II
Jun Wang1, Santhosh Kumar, Won-Tak Choi
1Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Protein and Peptide Letters
|June 28, 2006
Abstract:
Stepwise solid phase synthesis using the Fmoc chemistry is reported for a panel of 71-residue and novel unnatural chemokine analogs derived from vMIP-II. This demonstrates the feasibility of using this synthetic method to generate de novo designed protein ligand molecules to study the biology and pharmacology of chemokine receptors.
