Jove
Visualize
Contact Us

Related Experiment Videos

[Genetic predisposition in cutaneous melanoma].

José A Avilés1, Pablo Lázaro

  • 1Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España. dermaviles@gmail.com

Actas Dermo-Sifiliograficas
|June 28, 2006
PubMed
Summary

Melanoma incidence is rising globally. Research highlights ultraviolet radiation as a key environmental risk factor, alongside genetic factors like CDKN2A and MC1R, crucial for understanding melanoma development and prevention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries.

Journal of hepatology·2023
Same author

Challenge, fear and pride: nursing students working as nurses in COVID-19 care units.

International journal of qualitative studies on health and well-being·2022
Same author

Beyond visual acuity: Patient-relevant assessment measures of visual function in retinal diseases.

European journal of ophthalmology·2021
Same author

Cost-effectiveness of a Contact Intervention and a Psychotherapeutic Program for Post-discharge Suicide Prevention.

Canadian journal of psychiatry. Revue canadienne de psychiatrie·2020
Same author

Telemedicine efficiently improves access to hepatitis C management to achieve HCV elimination in the penitentiary setting.

The International journal on drug policy·2020
Same author

Hepatitis C reflex testing in Spain in 2019: A story of success.

Enfermedades infecciosas y microbiologia clinica (English ed.)·2020
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Dermatology and Genetics
  • Cancer Research

Context:

  • Global increase in cutaneous melanoma incidence over the past two decades.
  • Growing understanding of environmental and genetic risk factors for melanoma.

Purpose:

  • To explore the complex relationship between ultraviolet radiation and melanoma.
  • To investigate the roles of high-penetrance (CDKN2A) and low-penetrance (MC1R) genes in melanoma development.
  • To synthesize findings from international family, twin, and control studies.

Summary:

  • Ultraviolet radiation is the primary environmental risk factor for melanoma, though its role is complex.
  • CDKN2A (p16) is a high-penetrance gene associated with familial melanoma.
  • MC1R gene variants are linked to non-familial melanoma and influence pigmentation.

Related Experiment Videos

  • Functional studies of CDKN2A and MC1R provide insights into melanocyte biology and melanoma pathogenesis.

    • Impact:

    • Informs public health campaigns on sun exposure dangers and high-risk individual identification.
    • Advances understanding of melanoma genetics for improved primary and secondary prevention strategies.
    • Facilitates future discoveries through collaborative international research on melanoma risk factors.