Related Experiment Videos
Intracranial plasma cell-granuloma with extensive ossification
Unal Ozüm1, Hatice Ozer, Ozen Karadağ
1Department of Neurosurgery, Cumhuriyet University School of Medicine, Sivas, Turkey. ozum@cumhuriyet.edu.tr
British Journal of Neurosurgery
|June 28, 2006
Summary
Intracranial plasma-cell granuloma, a rare non-neoplastic condition, can present as an extensively ossified mass. This case highlights the importance of considering this rare entity in the differential diagnosis of intracranial calcified lesions.
Area of Science:
- Neurology
- Pathology
- Radiology
Background:
- Intracranial plasma-cell granuloma is a rare, non-neoplastic proliferation of plasma cells.
- It typically presents as a space-occupying lesion within the cranial cavity.
Observation:
- An 18-year-old female presented with an intracranial mass.
- Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) revealed a left frontoparietal lesion with extensive calcification and ossification.
Findings:
- Histopathology confirmed a diffuse inflammatory infiltrate predominantly of reactive plasma cells, alongside histiocytes, neutrophils, lymphocytes, lymphoplasmacytic cells, and eosinophils.
- The lesion exhibited widespread psammomatous and dystrophic calcifications, along with significant ossification featuring trabecular bone formation.
Implications:
- This case underscores the importance of including plasma-cell granuloma in the differential diagnosis for intracranial masses with calcification.
- The extensive ossification observed is an unusual feature that aids in radiological and pathological characterization.