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Related Concept Videos

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Pleural Effusion I: Introduction01:25

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Mechanical Ventilation II: Invasive Ventilation01:23

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Updated: Jun 28, 2026

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program
08:59

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Published on: February 25, 2015

Positive end-expiratory pressure ventilation increases extravascular lung water due to a decrease in lung lymph flow.

D M Maybauer1, P O Talke, M Westphal

  • 1Department of Anaesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, and Shriners Burns Hospital for Children at Galveston, USA.

Anaesthesia and Intensive Care
|June 29, 2006
PubMed
Summary
This summary is machine-generated.

Positive end-expiratory pressure (PEEP) increases extravascular lung water (EVLW) and decreases pulmonary lymph flow (QL) in sheep. These effects are reversible when PEEP is reduced, indicating a dynamic relationship between PEEP, EVLW, and lung fluid balance.

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Area of Science:

  • Physiology
  • Critical Care Medicine

Background:

  • Positive end-expiratory pressure (PEEP) is a cornerstone in managing respiratory failure, aiming to enhance gas exchange and lung aeration.
  • The precise impact of PEEP on extravascular lung water (EVLW) remains an area requiring further elucidation.
  • Understanding PEEP's effects on lung fluid dynamics is crucial for optimizing mechanical ventilation strategies.

Purpose of the Study:

  • To prospectively investigate the effects of PEEP on EVLW and pulmonary lymph flow (QL) in a physiological animal model.
  • To determine the reversibility of PEEP-induced changes in EVLW and QL.

Main Methods:

  • A prospective laboratory experiment was conducted on twelve adult sheep.
  • Measurements included cardiopulmonary hemodynamics, EVLW, QL, and arterial blood gases under varying PEEP levels (0 and 10 cmH2O).
  • Animals were mechanically ventilated in an awake state, with PEEP adjusted over a two-hour baseline, two hours at 10 cmH2O, and a return to baseline.

Main Results:

  • Increasing PEEP to 10 cmH2O significantly increased EVLW (498 ± 40 to 630 ± 58 ml) and decreased QL (7 ± 1 to 5 ± 1 ml/h).
  • These changes in EVLW and QL were reversible upon reducing PEEP back to baseline levels.
  • Cardiac output remained unaffected by the changes in PEEP.

Conclusions:

  • The application of PEEP leads to a reversible increase in EVLW in the lungs.
  • This increase in EVLW is associated with a corresponding decrease in pulmonary lymph flow.
  • PEEP influences lung fluid balance, highlighting the need for careful monitoring during mechanical ventilation.