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Updated: Aug 7, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

[Microscopic polyangiitis: an unusual case report]

A Despond1, Ch Brossard, S Moll

  • 1Service de Médecine Interne, Département de Médecine, CHUV, Lausanne.

Praxis
|June 29, 2006
PubMed

Insights

A woman with persistent pneumonia symptoms developed acute kidney injury. Diagnosis revealed microscopic polyangiitis, a condition effectively treated with corticosteroids and cyclophosphamide.

Area of Science:

  • Nephrology
  • Rheumatology
  • Pulmonology

Background:

  • Pneumonia can present with systemic inflammatory symptoms.
  • Acute kidney injury (AKI) can be a manifestation of systemic vasculitis.

Observation:

  • A 56-year-old woman presented with persistent fever and inflammatory syndrome post-pneumonia treatment.
  • She subsequently developed AKI, characterized by proteinuria, hematuria, and positive anti-neutrophil cytoplasmic antibodies.
  • Thoracic CT revealed nonspecific infiltrates.

Findings:

  • Renal biopsy confirmed microscopic polyangiitis (MPA).
  • MPA is a small-vessel vasculitis often associated with anti-neutrophil cytoplasmic antibodies (ANCA).

Implications:

  • Early diagnosis and treatment of MPA are crucial for preventing irreversible kidney damage.
  • Corticosteroids and cyclophosphamide are effective in inducing remission for MPA.
  • This case highlights the importance of considering systemic vasculitis in patients with unexplained inflammatory syndromes and AKI.

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