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[Functional and inflammatory bowel disorders].

Thomas Frieling1

  • 1Medizinische Klinik II, Klinik für Gastroenterologie, Hepatologie, Infektiologie, Neurogastroenterologie, Hämatologie und Onkologie, Krefeld. Frieling@Klinikum-Krefeld.de

Medizinische Klinik (Munich, Germany : 1983)
|June 29, 2006
PubMed
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Postinfectious irritable bowel syndrome (PI-IBS) may arise from subtle mucosal and enteric nervous system changes after infection. Diagnosis involves excluding alarm symptoms and identifying acute onset, fever, vomiting, or diarrhea.

Area of Science:

  • Gastroenterology
  • Immunology
  • Neurogastroenterology

Context:

  • Functional bowel disorders, particularly postinfectious irritable bowel syndrome (PI-IBS), may involve subtle postinflammatory changes.
  • These changes in the mucosa and enteric nervous system are often undetectable by standard diagnostic methods.
  • PI-IBS is defined by an acute onset of symptoms, including fever, vomiting, and diarrhea, following an initial gastrointestinal infection.

Purpose:

  • To explore the pathomechanisms underlying PI-IBS.
  • To outline diagnostic criteria and differential diagnoses for PI-IBS.
  • To review current therapeutic approaches for PI-IBS.

Summary:

  • Gastrointestinal infections can trigger subtle inflammation, altering mucosal function and the enteric nervous system.

Related Experiment Videos

  • Pathomechanisms involve genetic factors (IL-10 promoter polymorphism), cytokine-induced cell hyperplasia (Paneth, enteroendocrine cells), and neuroinflammation.
  • Diagnosis requires excluding alarm symptoms; standardized questionnaires offer high sensitivity and specificity for IBS. PI-IBS indicators include acute onset and infectious symptoms. Differential diagnoses are broad, and current therapies are symptomatic.

    • Impact:

    • Understanding PI-IBS pathomechanisms can guide future research into targeted therapies.
    • Improved diagnostic strategies may lead to earlier identification and management of PI-IBS.
    • Highlights the need for specific anti-inflammatory treatments for PI-IBS.