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Updated: Aug 7, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
Published on: February 14, 2021
[Chemoreflexsensitivity is reduced in obstructive sleep apnea and might be modulated by the autonomic system]
Stephan Steiner1, Marcus G Hennersdorf, Bodo E Strauer
1Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum Düsseldorf. steinest@uni-duesseldorf.de
Background:
Chemoreflexes are important mechanisms for regulating ventilatory and cardiovascular function, which are supposed to be influenced in obstructive sleep apnea (OSA).
Patients And Methods:
For determination of chemoreflexsensitivity (CHRS) the ratio of the RR-interval shift in the surface ECG during 5 min inhalation of oxygen via a nose mask was formed in 15 patients with suspected OSA. Noradrenaline plasma concentrations were measured and were correlated to CHRS.
Results:
Patients with OSA showed a reduced CHRS. CHRS was correlated to the severity of sleep apnea (respiratory disturbance index [RDI]; r = -0.622; p = 0.013), and to minimal nocturnal oxygen saturation (r = 0.594; p = 0.032). Reduced CHRS was associated with higher noradrenaline concentrations (r = -0.542; p = 0.037).
Conclusion:
CHRS is reduced in patients with OSA and correlates with the severity of OSA. Further on, CHRS might be modulated by the autonomic system. Therefore, the determination of CHRS enables to estimate sympathetic activation in these patients.
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