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Histamine in the developing sympathoadrenal system.

M Ahonen1, P Panula, O Häppölä

  • 1Department of Anatomy, University of Helsinki, Finland.

Agents and Actions
|May 1, 1991
PubMed
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Histamine and catecholamines develop in the rat sympathoadrenal system starting embryonic day 14.5. Histamine is found in nerve fibers and cells, later concentrating in specific sympathetic cell types.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pharmacology

Background:

  • The sympathoadrenal system is crucial for stress response and development.
  • Understanding the ontogeny of neurotransmitters like histamine and catecholamines is vital for developmental neuroscience.

Purpose of the Study:

  • To investigate the developmental timing and distribution of histamine in relation to catecholamines within the rat sympathoadrenal system.
  • To identify the specific cell types expressing histamine during embryonic and early postnatal development.

Main Methods:

  • Utilized indirect immunohistochemistry with a specific anti-histamine antiserum.
  • Employed tyrosine hydroxylase (TH) immunoreactivity as a marker for catecholamine synthesis.
  • Examined tissues from embryonic day 12.5 through to newborn rats.

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Main Results:

  • Tyrosine hydroxylase (TH) immunoreactivity, indicating catecholamine synthesis, appeared in sympathetic tissues between embryonic days 12.5 and 14.5.
  • Histamine immunoreactivity was detected starting from embryonic day 14.5, initially in nerve fibers and some cells.
  • By birth, histamine immunoreactivity localized to small intensely fluorescent (SIF) cells, paraganglion-type cells, and some adrenal medulla cells.

Conclusions:

  • Histamine expression in the rat sympathoadrenal system coincides with catecholamine synthesis.
  • Histamine immunoreactivity becomes restricted to specific subpopulations of sympathetic cells postnatally.
  • This study elucidates the ontogenetic relationship between histamine and catecholamines in the developing sympathoadrenal system.