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Published on: August 4, 2021
Microsatellite instability in endometrioid endometrial carcinoma: correlation with clinically relevant pathologic
L H Honoré1, J Hanson, S E Andrew
1Department of Laboratory Medicine, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada. lhonore@shaw.ca
Summary
Microsatellite instability (MSI) in endometrial cancer is linked to more aggressive tumor features. This finding helps understand the molecular basis of disease progression and guides potential therapeutic strategies.
Area of Science:
- Oncology
- Pathology
- Molecular Genetics
Background:
- Endometrioid endometrial carcinoma is a common gynecologic malignancy.
- Microsatellite instability (MSI) is a known molecular marker in various cancers.
- Understanding MSI's correlation with clinicopathologic features is crucial for prognosis.
Purpose of the Study:
- To investigate the association between MSI, determined by the BAT26 method, and prognostic/therapeutic variables in endometrioid endometrial carcinoma.
- To elucidate the molecular genetic underpinnings of these correlations.
Main Methods:
- Analysis of 218 patients with endometrioid endometrial carcinoma.
- Assessment of microsatellite instability (MSI) using the BAT26 method.
- Correlation of MSI status with established clinicopathologic variables.
Main Results:
- MSI positively correlated with higher tumor grade, endometrial atrophy, squamous metaplasia, isthmic involvement, deeper myoinvasion, vascular invasion, extrauterine spread, and extramyometrial angiolymphatic spread.
- No significant correlation was found with adenomyosis, mucinous metaplasia, tumor size, cornual involvement, cervical extension, uterine serosal involvement, or lymphoid response.
Conclusions:
- MSI is associated with several adverse prognostic and potentially therapeutic variables in endometrioid endometrial carcinoma.
- These findings provide insights into the molecular pathways influencing tumor behavior and progression.