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Updated: Jul 29, 2026
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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
Published on: September 11, 2012
Review article: intestinal failure
S Lal1, A Teubner, J L Shaffer
1Intestinal Failure Unit, Hope Hospital, Salford, UK.
Alimentary Pharmacology & Therapeutics
|June 29, 2006
Summary
Intestinal failure occurs when the body cannot absorb nutrients. Type 2 intestinal failure requires a multidisciplinary approach for management, involving nutritional support and addressing complications to prevent long-term parenteral nutrition dependence.
Area of Science:
- Gastroenterology
- Clinical Nutrition
- Surgical Science
Background:
- Intestinal failure is defined by the inability to maintain nutrient balance due to intestinal resection or malabsorption.
- It presents in varied forms, including self-limiting Type 1 and more complex Type 2, often following surgery for conditions like Crohn's disease.
Purpose of the Study:
- To review the causes and management of intestinal failure.
- To highlight the critical need for a multidisciplinary approach in managing Type 2 intestinal failure.
Main Methods:
- A MEDLINE search was conducted from 1966 to 2006.
- Keywords included "intestinal failure," "parenteral nutrition," "enteral nutrition," "intestinal fistula," and "short bowel syndrome."
Main Results:
- Type 1 intestinal failure is common after abdominal surgery, requiring short-term support.
- Type 2 intestinal failure involves severe complications and necessitates comprehensive management before surgical reconstruction.
- A structured approach can prevent progression to Type 3 intestinal failure, defined by long-term parenteral nutrition dependency.
Conclusions:
- Effective management of Type 2 intestinal failure is crucial for patient outcomes.
- A multidisciplinary strategy is essential for nutritional repletion and complication management.
- Preventing progression to long-term parenteral nutrition is a key goal in treating complex intestinal failure.
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