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Abdominal pain accompanied by weight loss may increase the diagnostic yield of capsule endoscopy: a Korean
Ki-Nam Shim1, Yong-Sik Kim, Kyung-Jo Kim
1Ewha Womans University College of Medicine, and Yang Hospital, Seoul, Korea.
Insights
Capsule endoscopy (CE) aids in diagnosing unexplained abdominal pain, especially when weight loss is present. This diagnostic tool offers valuable insights for patients with persistent GI symptoms not identified by other methods.
Area of Science:
- Gastroenterology
- Diagnostic Imaging
- Endoscopy
Background:
- Capsule endoscopy (CE) is established for obscure gastrointestinal (GI) bleeding.
- Its utility for other small-bowel disorders is less defined.
- Evaluating unexplained abdominal pain with CE requires further investigation.
Purpose of the Study:
- To determine the subgroup of patients with unexplained abdominal pain who would benefit from CE.
- To assess the diagnostic yield of CE in this patient population.
Main Methods:
- Retrospective analysis of 110 patients with unexplained abdominal pain.
- Data collected from 12 tertiary referral centers (September 2002 - September 2004).
- Inclusion criteria: patients with unexplained abdominal pain.
Main Results:
- Successful small bowel visualization achieved in 69.1% of cases.
- Positive findings explaining symptoms in 17.3% of patients (19/110).
- Significant associations with positive CE findings included weight loss, elevated ESR, elevated CRP, and hypoalbuminemia. Weight loss was a significant independent risk factor (OR, 18.6; p=0.02).
Conclusions:
- CE is a valuable tool for diagnosing unexplained abdominal pain when accompanied by weight loss.
- CE can identify various small-bowel pathologies contributing to abdominal pain.
- Further research may refine CE's role in specific abdominal pain subgroups.
Objective:
Capsule endoscopy (CE) is approved for the evaluation of obscure gastrointestinal (GI) bleeding and its use has increased in the assessment of patients with various small-bowel disorders. The yield of CE for indications of disorders other than GI bleeding is not yet well described. The aim of the present study was to determine in which subgroup of patients with unexplained abdominal pain, CE would be a helpful evaluation tool.
Material And Methods:
The results of CE in 110 patients (70 M, 40 F, mean age 50.8+/-14.1 years) with unexplained abdominal pain from 12 tertiary referral centers between September 2002 and September 2004 were retrospectively analyzed.
Results:
The visualization of the small bowel to the cecum was successfully carried out in 69.1% of the patients. Nineteen out of the 110 cases revealed positive findings that explained the symptoms of the patient (diagnostic yield=17.3%). Diagnosis included small-bowel stricture (5), Crohn's disease (3), small-bowel tumor (2), radiation-induced enteritis (1), NSAID-induced enteropathy (1), ischemic ileitis (1), diffuse lymphangiectasia (1), and significant erosion or ulceration (5). By univariate logistic regression analysis, the positive findings of CE were significantly associated with weight loss (odds ratio (OR), 11.9; 95% CI [2.0, 70.6]), elevated erythrocyte sedimentation rate (ESR) (>20 mm/h) (OR, 11.5; 95% CI (1.9, 69.5)), elevated C-reactive protein (CRP) (>or=0.4 mg/dL) (OR, 5.0; 95% CI (1.6, 15.9)), and hypoalbuminemia (albumin<3 g/dL) (OR, 23.1; 95% CI (2.4, 223.1)). Using a multivariate analysis, weight loss was found to be a significant risk factor for positive findings of CE (OR, 18.6; 95% CI (1.6, 222.4), p=0.02).
Conclusions:
The results of this study suggest that CE can be helpful in patients suffering from abdominal pain that cannot be explained by established examinations, if the pain is accompanied by weight loss.
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