Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-dependent decrease in renal glucocorticoid receptor function is reversed by dietary restriction in mice.

Ramesh Sharma1, Debipreeta Dutta

  • 1Department of Biochemistry, North Eastern Hill University, Shillong, India. sharamesh@gmail.com

Annals of the New York Academy of Sciences
|June 29, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Energy harvesting potential of LiHfIrZ (Z = Si, Ge) quaternary Heusler alloys: a first-principles computational study.

Scientific reports·2026
Same author

LiMPtTl (M = Ti, Zr) Heusler alloys for high-performance energy harvesting: a DFT study.

Scientific reports·2026
Same author

DFT-driven insights into (Sr/Ba)<sub>2</sub>GaBiO<sub>6</sub> double perovskites for next-generation optoelectronic and thermoelectric technologies.

Scientific reports·2026
Same author

Corrigendum to "Microwave-assisted assembly of Ag<sub>2</sub>O-ZnO composite nanocones for electrochemical detection of 4-Nitrophenol and assessment of their photocatalytic activity towards degradation of 4-nitrophenol and methylene blue dye" [J Hazard Mater 416 (2021) 125771].

Journal of hazardous materials·2026
Same author

First-principles identification of PtTiGe and PtTiPb as high-efficiency thermoelectric half-Heuslers.

Scientific reports·2026
Same author

First-principles study of CO<sub>2</sub> activation on pristine and defected XO<sub>2</sub> (X= Pd, Pt) monolayers.

Journal of molecular graphics & modelling·2026
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Dietary restriction (DR) in older mice increased kidney glucocorticoid receptors (GRs) concentration and activation, reversing age-related declines. This suggests DR may improve kidney function and adaptability in aging animals.

Area of Science:

  • Endocrinology
  • Gerontology
  • Molecular Biology

Background:

  • Aging is associated with decreased glucocorticoid receptor (GR) function in the kidney.
  • Dietary restriction (DR) is known to influence aging processes and cellular functions.

Purpose of the Study:

  • To investigate the effects of age and DR on renal GR concentration, activation, and nuclear binding.
  • To determine if DR can mitigate age-related decreases in GR function.

Main Methods:

  • Male mice (5 and 20 months old) were subjected to ad libitum (AL) feeding or alternate-day DR for 3 months.
  • Quantification of renal GRs using Scatchard and slot blot analyses.
  • Assessment of GR activation via salt and heat treatments, and DNase I digestion of nuclear-bound complexes.

Related Experiment Videos

Main Results:

  • Older AL-fed mice showed a 30% decrease in renal GR concentration compared to adult mice.
  • DR significantly increased GR levels (28%) in older mice compared to AL-fed controls.
  • DR enhanced GR activation (30%) and did not alter nuclear complex digestibility in older mice.

Conclusions:

  • Dietary restriction can reverse age-related declines in renal glucocorticoid receptor concentration and function.
  • DR may enhance kidney adaptability in older animals, potentially improving water and electrolyte balance.