Establishment of H2O2-induced premature senescence in human fibroblasts concomitant with increased cellular
Stephanie Zdanov1, Jose Remacle, Olivier Toussaint
1Unit of Cellular Biochemistry and Biology, the University of Namur, Belgium.
Annals of the New York Academy of Sciences
|June 29, 2006
Abstract:
Premature senescence of human fibroblasts is established after exposure to an acute sublethal concentration of H(2)O(2). Overexpression of transforming growth factor-beta1 (TGF-beta1) was shown to be responsible for the appearance of the biomarkers of senescence in these conditions. Other studies have shown that incubation of human fibroblasts with TGF-beta1 leads to overexpression of H(2)O(2). In this work, we show an increased production of H(2)O(2) by human fibroblasts as premature senescence is established after an initial exposure to H(2)O(2).
