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Published on: July 9, 2013
Proteasomal oscillation during mild heat shock in aging human skin fibroblasts
David Christian Kraft1, Custer C Deocaris, Suresh I S Rattan
1Laboratory of Cellular Aging, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Denmark.
Abstract:
Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat-stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation.
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