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Related Experiment Videos

Oral mesalamine and clinical remission are associated with a decrease in the extent of long-standing ulcerative

Michael F Picco1, Murli Krishna, John R Cangemi

  • 1Mayo Clinic, Jacksonville, Florida 32224, USA. picco.michael@mayo.edu

Inflammatory Bowel Diseases
|June 29, 2006
PubMed
Summary

Surveillance biopsy accurately determines ulcerative colitis (UC) extent, unlike colonoscopy alone. Oral mesalamine and disease remission correlate with reduced UC extent over time.

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Area of Science:

  • Gastroenterology
  • Inflammatory Bowel Disease Research
  • Colorectal Cancer Screening

Background:

  • Long-standing ulcerative colitis (UC) requires accurate monitoring of disease extent.
  • Colonoscopy alone may not precisely determine the anatomic extent of UC.
  • Surveillance biopsies are crucial for assessing histologic changes over time.

Purpose of the Study:

  • Compare colonoscopy with surveillance biopsy for determining UC extent.
  • Evaluate factors influencing changes in UC histologic extent.
  • Assess the impact of mesalamine and disease activity on UC extent.

Main Methods:

  • Compared colonoscopy and surveillance biopsy in 212 UC patients.
  • Analyzed changes in histologic extent in 102 patients with serial biopsies.

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  • Assessed influences of mesalamine, disease activity, and other factors.

    • Main Results:

    • Colonoscopy showed poor agreement with biopsy findings, under- or overestimating extent.
    • Histologic extent remained stable in 60.8% of patients between procedures.
    • Clinical remission and oral mesalamine use were linked to decreased UC extent.

    Conclusions:

    • Surveillance biopsy is the preferred method for determining UC extent.
    • Histologic extent in long-standing UC can fluctuate.
    • Disease remission and oral mesalamine are associated with reduced UC extent.