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NOD2/CARD15 gene polymorphisms are not associated with collagenous colitis
Ahmed Madisch1, Stephan Hellmig, Stephan Schreiber
1Medical Department I, Technical University Hospital, Fetscherstr. 74, D-01307 Dresden, Germany. ahmed.madisch@uniklinikum-dresden.de
International Journal of Colorectal Disease
|June 29, 2006
Summary
This study investigated if specific gene variations influence collagenous colitis risk. Researchers found no significant link between NOD2/CARD15 gene polymorphisms and collagenous colitis susceptibility.
Area of Science:
- Gastroenterology
- Genetics
- Immunology
Background:
- Collagenous colitis is a chronic inflammatory bowel disease with an unknown cause.
- Histomorphological features can resemble other inflammatory bowel diseases.
Purpose of the Study:
- To evaluate the role of functional NOD2/CARD15 gene polymorphisms in collagenous colitis susceptibility.
- A case-control study design was employed.
Main Methods:
- Genotyping of 75 collagenous colitis patients and 534 healthy donors for NOD2/CARD15 gene SNPs (8, 12, 13) using TaqMan technology.
- Chi-squared test was used to compare carrier status of rare alleles.
Main Results:
- Carrier frequencies for rare alleles in SNP 8, 12, and 13 were similar between patients (9.5%, 1.3%, 8.1%) and controls (8.9%, 1.1%, 8.4%).
- No statistically significant differences were observed in allele, genotype, or carrier frequencies (p>0.05).
Conclusions:
- Functional polymorphisms in the NOD2/CARD15 gene do not appear to be associated with collagenous colitis susceptibility.
- Further research may be needed to explore other genetic factors.
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