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Updated: Aug 7, 2026

Laser-Induced Chronic Ocular Hypertension Model on SD Rats
Published on: December 4, 2007
[Severe ocular side effects with Topamax]
V M Asensio-Sánchez1, B Torreblanca-Agüera, S Martínez-Calvo
1Hospital General, Medina del Campo, Valladolid, España. vasensio@hmdc.sacyl.es
Case Reports:
We describe 2 patients who developed ocular side effects during treatment with topiramate. One was a 16-year-old woman with generalized seizures who developed a homonymous hemianopia after using topiramate 125 mg per day for 12 weeks, and the other was a 24-year-old epileptic female who developed a bilateral maculopathy after using topiramate 150 mg per day for 8 weeks.
Discussion:
We identified two severe ocular adverse reactions from topiramate. Both reactions necessitated discontinuing the treatment, but the topiramate-associated maculopathy was irreversible.
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