Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Endothelial progenitor cells and atherosclerosis].

Saher Hamed1, Ariel Roguin

  • 1Department of Cardiology, Rambam Medical Center, B. Rappaport Faculty of Medicine, Technion Israel Institute of Technology Haifa, Israel.

Harefuah
|June 30, 2006
PubMed
Summary

Cardiovascular risk factors impair endothelial progenitor cells (EPCs), crucial for blood vessel repair. This impairment hinders the body's ability to heal, potentially worsening atherosclerosis and cardiovascular disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of COVID-19 pandemic on admission, management and mortality of pulmonary embolism in cancer patients.

International journal of cardiology. Cardiovascular risk and prevention·2026
Same author

Pelvic Lead Apron Shielding During Transradial Approach: Simple and Affordable Method to Reduce Scatter Radiation.

JACC. Cardiovascular interventions·2026
Same author

Frailty Impact on Periprocedural Outcomes of Atrial Fibrillation Ablation.

Journal of clinical medicine·2026
Same author

Mitral regurgitation and in-hospital outcomes of percutaneous left atrial appendage closure.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2025
Same author

Anticoagulation Strategies for Left Ventricular Thrombus After Myocardial Infarction: A Review.

Journal of clinical medicine·2025
Same author

Impact of cardiovascular-kidney-metabolic syndrome staging on clinical outcomes and management of acute pulmonary embolism: A comprehensive analysis.

International journal of cardiology. Heart & vasculature·2025

Area of Science:

  • Vascular biology and regenerative medicine.
  • Cardiovascular disease research.
  • Endothelial cell function and dysfunction.

Context:

  • Atherosclerosis involves endothelial monolayer damage, leading to cell apoptosis and compromised vessel integrity.
  • Endothelial progenitor cells (EPCs) are vital for repairing damaged blood vessels and forming new ones.
  • Cardiovascular risk factors negatively impact EPC number and function.

Purpose:

  • To review the role of EPCs in atherosclerosis and cardiovascular outcomes.
  • To explore how cardiovascular risk factors affect EPCs.
  • To highlight potential therapeutic strategies for enhancing EPC function.

Summary:

  • Endothelial progenitor cells (EPCs) are critical for vascular repair and limiting atherosclerotic lesion formation.

Related Experiment Videos

  • Risk factors like age, smoking, hypertension, hyperlipidemia, and diabetes reduce EPCs' number and functional activity.
  • Impaired EPCs contribute to atherogenesis and disease progression, limiting regenerative capacity.

    • Impact:

    • EPCs serve as important biomarkers for atherosclerosis and predicting cardiovascular outcomes.
    • Understanding EPC impairment by risk factors offers insights into disease mechanisms.
    • Novel strategies targeting the injury-repair balance could improve therapeutic prospects for cardiovascular diseases.