Related Experiment Video
Updated: Aug 7, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata
Ping-Chung Kuo1, Tsung-Hsiao Kuo, Amooru G Damu
1Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Abstract:
[reaction: see text] A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC(50) values less than 4 microg/mL.