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Updated: Aug 3, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Adjuvant chemotherapy for early-stage non-small cell lung cancer: the past, the present and the future
Anil Potti1, Apar Kishor Ganti
1Duke Institute for Genome Sciences and Policy, Division of Hematology, Duke University Medical Center, Box #3382, CIEMAS, Durham, NC 27710, USA. anil.potti@duke.edu
Abstract:
Complete resection is mandatory in order to achieve a cure in patients with early-stage non-small cell lung cancer (NSCLC). However, despite complete resection, a substantial proportion of patients have disease recurrence, with distant metastases being the primary sites of failure. Recent trials have conclusively demonstrated the benefit of platinum-based adjuvant therapy in patients with resected stage IB and II NSCLC. The role of adjuvant chemotherapy in resected stage III NSCLC is less clear, with trials showing conflicting results. The role of targeted agents in this setting is being investigated. Gene expression profiling studies should help direct chemotherapy to those who would actually benefit from it, thereby saving others from unnecessary toxicity.
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