Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transport catalysis.

Martin Klingenberg1

  • 1Institute Physiological Chemistry, University of Munich, Schillerstr 44, 80336 München, Germany. klingenberg@med.uni-muenchen.de

Biochimica Et Biophysica Acta
|June 30, 2006
PubMed
Summary

Carrier-mediated solute transport utilizes an "induced transition fit" mechanism, lowering activation energy barriers. This catalytic viewpoint explains substrate affinity, energy requirements, and inhibitor effects in biomembrane transport.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

UCP1 - A sophisticated energy valve.

Biochimie·2016
Same author

Dataset of the AAC2 conformations in the c-, intermediate- and m-states obtained from free-energy simulations.

Data in brief·2016
Same author

The switching mechanism of the mitochondrial ADP/ATP carrier explored by free-energy landscapes.

Biochimica et biophysica acta·2016
Same author

Wanderings in bioenergetics and biomembranes.

Biochimica et biophysica acta·2010
Same author

Cardiolipin and mitochondrial carriers.

Biochimica et biophysica acta·2009
Same author

The ADP and ATP transport in mitochondria and its carrier.

Biochimica et biophysica acta·2008

Area of Science:

  • Biochemistry
  • Biophysics
  • Membrane Transport

Background:

  • Carrier-mediated transport is crucial for biomembrane function.
  • Understanding the catalytic principles governing carrier transport is essential.

Purpose of the Study:

  • To analyze carrier-linked solute transport through biomembranes from a catalytic perspective.
  • To introduce and explain the

Main Methods:

  • Theoretical analysis of carrier-mediated transport.
  • Application of catalytic principles to biomembrane transport models.

Main Results:

  • Carrier transport differs from enzymatic catalysis; substrates induce optimal fit in the transition state.
  • Enhanced intrinsic binding energy compensates for conformational changes, reducing the activation energy barrier.
  • The

Conclusions:

  • The