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Related Experiment Videos

Is optimal gene order impossible?

Juan F Poyatos1, Laurence D Hurst

  • 1Evolutionary Systems Biology Initiative, Structural and Computational Biology Programme, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain. jpoyatos@cnio.es

Trends in Genetics : TIG
|June 30, 2006
PubMed
Summary
This summary is machine-generated.

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Genes close in protein networks are linked and co-expressed. However, these linked genes show high recombination rates, preventing stable gene clustering. This suggests a dynamic evolutionary cycle of gene order.

Area of Science:

  • Genomics
  • Systems Biology
  • Molecular Evolution

Background:

  • Genes encoding proteins within the same complex often exhibit linkage and co-expression.
  • Genes physically close in protein interaction networks are frequently linked and co-expressed.

Purpose of the Study:

  • To investigate the relationship between gene proximity in protein interaction networks, physical linkage, and co-expression.
  • To explore the role of recombination rates in the stability of gene clusters.

Main Methods:

  • Analysis of gene linkage and co-expression patterns based on protein interaction network proximity.
  • Measurement and comparison of recombination rates for linked genes in network proximity.

Main Results:

Related Experiment Videos

  • Genes close in the protein interaction network are more often linked and co-expressed than expected.
  • Unexpectedly high recombination rates were observed for linked genes in network proximity.
  • High recombination rates correlate with increased genome re-organization.

    • Conclusions:

    • The observed high recombination rates may counteract gene clustering, leading to a weak clustering effect in networks.
    • A co-evolutionary cycle involving physical linkage, co-expression, increased recombination, and cluster breakup might explain the dynamic nature of gene order.
    • Optimal gene order is likely unstable due to this evolutionary cycle.