Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrating patterns of polymorphism at SNPs and STRs.

Bret A Payseur1, Asher D Cutter

  • 1Laboratory of Genetics, University of Wisconsin, Genetics/Biotechnology 2428, 425-G Henry Mall, Madison, WI 53706, USA. payseur@wisc.edu

Trends in Genetics : TIG
|June 30, 2006
PubMed
Summary

Contrasting mutation rates in single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs) weakly correlate their patterns, despite shared ancestry. Understanding these population genetics dynamics is crucial for accurate inference.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An in vivo parallelized reporter assay to uncover tissue-specific splicing regulatory sequences in a multicellular animal.

Nucleic acids research·2026
Same author

Global genomic diversity of the selfing nematode <i>Caenorhabditis tropicalis</i> correlates with geography.

bioRxiv : the preprint server for biology·2026
Same author

<i>Caenorhabditis briggsae</i> ancestral genomic hyper-diversity contrasts with globally distributed genome-wide haplotypes.

bioRxiv : the preprint server for biology·2025
Same author

Elevated mutation near crossovers inhibits the evolution of recombination.

bioRxiv : the preprint server for biology·2025
Same author

The X chromosome and the emergence of reproductive isolation.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

The Genomic Imprint of Chromosomal Inversions and Demographic History in Island Populations of Deer Mice.

Molecular biology and evolution·2025

Area of Science:

  • Population genetics
  • Molecular evolution

Background:

  • Single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs) are widely used genetic markers.
  • SNPs and STRs exhibit distinct mutation rates and mechanisms.
  • Analyzing both marker types simultaneously can offer unique population genetic insights.

Purpose of the Study:

  • To model the correlation between polymorphism patterns at linked SNPs and STRs.
  • To investigate the influence of contrasting mutational dynamics and shared genealogy on this correlation.

Main Methods:

  • Coalescent simulations were employed to model genetic polymorphism.
  • The study simulated linked SNPs and STRs with divergent mutational processes.

Main Results:

Related Experiment Videos

  • Polymorphism patterns at linked SNPs and STRs showed only a weak correlation.
  • Divergent mutational processes significantly impact the correlation, overriding shared genealogical history.

    • Conclusions:

    • The distinct evolutionary dynamics of SNPs and STRs limit the correlation of their polymorphism patterns.
    • This highlights the necessity of considering marker-specific mutation processes for robust population genetic inference.
    • Further theoretical studies are needed to fully elucidate these relationships.