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Published on: August 2, 2011
Bird flu, influenza and 1918: the case for mutant Avian tuberculosis
Abstract:
Influenza is Italian for "influence", Latin: influentia. It used to be thought that the disease was caused by a bad influence from the heavens. Influenza was called a virus long, long before it was proven to be one. In 2005, an article in the New England Journal of Medicine estimated that a recurrence of the 1918 influenza epidemic could kill between 180 million and 360 million people worldwide. A large part of the current bird-flu hysteria is fostered by a distrust among the lay and scientific community regarding the actual state of our knowledge regarding the bird flu or H5N1 and the killer "Influenza" Pandemic of 1918 that it is compared to. And this distrust is not completely unfounded. Traditionally, "flu" does not kill. Experts, including Peter Palese of the Mount School of Medicine in Manhattan, remind us that even in 1992, millions in China already had antibodies to H5N1, meaning that they had contracted it and that their immune system had little trouble fending it off. Dr. Andrew Noymer and Michel Garenne, UC Berkely demographers, reported in 2000 convincing statistics showing that undetected tuberculosis may have been the real killer in the 1918 flu epidemic. Aware of recent attempts to isolate the "Influenza virus" on human cadavers and their specimens, Noymer and Garenne summed that: "Frustratingly, these findings have not answered the question why the 1918 virus was so virulent, nor do they offer an explanation for the unusual age profile of deaths". Bird flu would certainly be diagnosed in the hospital today as Acute Respiratory Distress Syndrome (ARDS). Roger and others favor suspecting tuberculosis in all cases of acute respiratory failure of unknown origin. By 1918, it could be said, in so far as tuberculosis was concerned, that the world was a supersaturated sponge ready to ignite and that among its most vulnerable parts was the very Midwest where the 1918 unknown pandemic began. It is theorized that the lethal pig epidemic that began in Kansas just prior to the first human outbreaks was a disease of avian and human tuberculosis genetically combined through mycobacteriophage interchange, with the pig, susceptible to both, as its involuntary living culture medium. What are the implications of mistaking a virus such as Influenza A for what mycobacterial disease is actually causing? They would be disastrous, with useless treatment and preventative stockpiles. The obvious need for further investigation is presently imminent and pressing.
Insights
The 1918 influenza pandemic may have been caused by tuberculosis, not a virus. This challenges current understanding and highlights the need for accurate diagnosis to prevent ineffective treatments for respiratory illnesses.
Area of Science:
- Epidemiology
- Virology
- Microbiology
Background:
- The 1918 influenza pandemic's high mortality rate remains debated.
- Traditional influenza (flu) is not typically fatal, raising questions about the 1918 event.
- Bird flu (H5N1) and the 1918 pandemic are often compared, but knowledge gaps exist.
Discussion:
- Undetected tuberculosis may have been the primary cause of death during the 1918 flu epidemic.
- The virulence and unusual age distribution of deaths in 1918 are not explained by viral theories alone.
- Avian and human tuberculosis, potentially combined in pigs, could explain the 1918 pandemic's lethality.
Key Insights:
- Mistaking mycobacterial disease for influenza A could lead to disastrous public health outcomes.
- Accurate diagnosis is crucial for effective treatment and stockpiling of medical resources.
- Re-evaluating the role of tuberculosis in historical respiratory pandemics is warranted.
Outlook:
- Further investigation into the etiology of the 1918 pandemic is urgently needed.
- Differential diagnosis for acute respiratory failure should include mycobacterial infections.
- Understanding historical pandemics can inform current public health strategies against novel respiratory diseases.
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