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Related Experiment Videos

[A mild blackwater fever].

M-A Bouldouyre1, D Dia, T Carmoi

  • 1Clinique Brévié, hôpital Principal, Dakar, Sénégal. mariebouldouyre@netcourrier.com

Medecine Et Maladies Infectieuses
|June 30, 2006
PubMed
Summary
This summary is machine-generated.

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A moderately severe case of blackwater fever occurred in a French woman self-medicating with halofantrine for malaria. This case highlights potential risks and contraindications for antimalarial drugs, even in less severe presentations.

Area of Science:

  • Tropical Medicine
  • Pharmacovigilance

Background:

  • Blackwater fever, a severe complication of malaria treatment, is often associated with quinine but can occur with other antimalarials.
  • Self-medication with antimalarials like halofantrine poses risks, especially in endemic areas like Guinea Bissau.

Observation:

  • A French expatriate in Guinea Bissau presented with symptoms of blackwater fever after self-medicating with halofantrine.
  • Clinical presentation included fever, jaundice, dark-red urine, hemolysis, and acute kidney injury, despite continued halofantrine treatment.
  • Sepsis was ruled out by blood examinations, confirming a diagnosis of blackwater fever.

Findings:

  • The patient experienced moderately severe hemolysis (hemoglobin 8.1 g/dl, positive Coombs test, elevated LDH) and renal failure (34 ml/min clearance).

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  • The patient recovered favorably following rehydration therapy.
  • This case underscores that blackwater fever can occur in moderately severe forms, not exclusively severe presentations.

    • Implications:

    • Blackwater fever necessitates strict contraindication of quinine, halofantrine, and mefloquine due to potential for severe adverse reactions.
    • Clinicians must be aware of blackwater fever, even in moderate forms, to prevent misdiagnosis and inappropriate treatment.
    • Recognition of moderate blackwater fever is crucial for patient safety and effective management of malaria treatment complications.