Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tocilizumab in the treatment of COVID-19-a meta-analysis.

QJM : monthly journal of the Association of Physicians·2021
Same author

Ongoing tuberculosis transmission among second-generation Ethiopian immigrants.

Epidemiology and infection·2020
Same author

Comparison of clinical outcomes of influenza A and B at the 2017-2018 influenza season: a cohort study.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2020
Same author

Measles-related hospitalizations and associated complications in Jerusalem, 2018-2019.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
Same author

High blood glucose variability is associated with bacteremia and mortality in patients hospitalized with acute infection.

QJM : monthly journal of the Association of Physicians·2018
Same author

Challenges raised by the increased uptake of new anticoagulants.

QJM : monthly journal of the Association of Physicians·2018

Related Experiment Video

Updated: Jul 22, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

Tuberculosis outbreak among students in a boarding school.

C Stein-Zamir1, I Volovik, S Rishpon

  • 1Jerusalem District Health Office, Ministry of Health and Braun School of Public Health and Community Medicine, Hebrew University, Hadassah Jerusalem, Israel. chen@lbjer.health.gov.il

The European Respiratory Journal
|June 30, 2006
PubMed
Summary

Investigating a tuberculosis outbreak in an Israeli boarding school revealed that close contact, immigration, and BCG vaccination significantly impact tuberculin skin test results. Directly observed therapy successfully prevented further cases.

More Related Videos

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
10:41

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)

Published on: April 30, 2020

Related Experiment Videos

Last Updated: Jul 22, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
10:41

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)

Published on: April 30, 2020

Area of Science:

  • Epidemiology
  • Public Health
  • Infectious Disease Control

Background:

  • Tuberculosis (TB) outbreaks pose significant public health challenges.
  • Six active TB cases were identified in an Israeli boarding school within one year.

Purpose of the Study:

  • To investigate a TB outbreak in a boarding school.
  • To identify factors associated with tuberculin skin test (TST) reactions.
  • To evaluate the effectiveness of implemented control measures.

Main Methods:

  • Epidemiological investigation including interviews and chest radiographs.
  • Tuberculin skin testing (TST) and repeated (two-step) TST for close contacts.
  • Molecular analysis to identify transmission patterns.
  • Directly observed therapy (DOT) for preventive treatment.

Main Results:

  • An epidemiological association was found among five TB cases, with a distinct molecular pattern.
  • Close contact, country of origin, and prior Bacillus Calmette-Guérin (BCG) vaccination were significantly associated with TST reactions.
  • Preventive DOT was completed by 91.3% of students.
  • No additional TB cases emerged during a 5-year follow-up period.

Conclusions:

  • The degree of contact is a key predictor for positive TST results during TB outbreak investigations.
  • Immigration from endemic countries and prior BCG vaccination influence TST outcomes.
  • Directly observed therapy is an effective strategy for preventing further TB morbidity.