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Heterogeneity in human soluble guanylate cyclase due to alternative splicing
V Chhajlani1, P A Frändberg, J Ahlner
1Department of Pharmacology, Umeå University, Sweden.
FEBS Letters
|September 23, 1991
Abstract:
Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.