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Interleukin-10 promoter polymorphism and venous thrombosis: a case-control study
Eva Cochery-Nouvellon1, Fabien Vitry, Pascale Cornillet-Lefebvre
1Laboratoire Central d'hématologie, CHU Robert Debré, Université de Reims Champagne-Ardenne, France. pnguyen@chu-reims.fr
Thrombosis and Haemostasis
|June 30, 2006
Summary
Certain interleukin-10 (IL-10) promoter gene polymorphisms are independent risk factors for venous thrombosis. The IL-10 G10 allele is also associated with recurrent venous thromboembolic events.
Area of Science:
- Genetics
- Immunology
- Thrombosis
Background:
- The human interleukin-10 (IL-10) promoter gene exhibits significant polymorphism.
- IL-10 polymorphisms are linked to autoimmune and lymphoproliferative diseases.
- IL-10 influences thrombin generation, but its role in venous thrombosis risk is unclear.
Purpose of the Study:
- To investigate whether IL-10 promoter gene polymorphisms are risk factors for venous thrombosis.
- To compare IL-10 genotypes between venous thromboembolism patients and healthy controls.
Main Methods:
- A case-control study involving 74 venous thromboembolism patients and 100 healthy Caucasian controls.
- Analysis of five IL-10 promoter gene polymorphisms (IL-10 R, IL-10G, -1082, -819, -592).
- Determination of Factor V G1691A Leiden mutation and multivariate logistic regression analysis.
Main Results:
- IL-10 G13 and G10 alleles were identified as independent risk factors for venous thrombosis (OR = 3.33, p = 0.003 and OR = 2.83, p = 0.03, respectively).
- The IL-10 G10 allele was found to be more prevalent in patients with recurrent venous disease.
Conclusions:
- Specific IL-10 promoter polymorphisms, particularly the G13 and G10 alleles, increase the risk of venous thrombosis.
- IL-10 gene polymorphisms may play a role in the pathogenesis of venous thromboembolism and recurrence.
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