Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Direct-to-patient BRCA1 testing: the Twoj Styl experience.

Jacek Gronwald1, Tomasz Huzarski, Tomasz Byrski

  • 1Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Polabska 4, 70-115, Szczecin, Poland. jgron@uoo.univ.szczecin.pl

Breast Cancer Research and Treatment
|June 30, 2006
PubMed
Summary

A public health initiative offered free BRCA1 genetic testing to Polish women via a magazine announcement. This efficient model identified mutations cost-effectively and improved screening compliance among carriers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Potential Role of Vitamin D in <i>BRCA1</i> Pathogenic Variant Carriers: A Narrative Review.

International journal of molecular sciences·2026
Same author

PCSK9 rs562556 variant and survival in BRCA1 mutation carriers and mutation-negative familial breast cancer.

NPJ breast cancer·2026
Same author

Association analysis of germline variants in GEN1 with a susceptibility to prostate cancer in Polish men.

Hereditary cancer in clinical practice·2026
Same author

Are current Polish guidelines for prophylactic mastectomy sufficient?

Hereditary cancer in clinical practice·2026
Same author

Germline ATRIP variants and the risk of ovarian cancer.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same author

The contribution of rare germline variants to the immune landscape of breast cancer.

Genome medicine·2026

Area of Science:

  • Oncology
  • Genetics
  • Public Health

Background:

  • Expanding preventive options for hereditary breast cancer increases demand for genetic testing.
  • Access to genetic testing is limited by cost and physician recognition of eligible candidates.
  • Public awareness campaigns can improve access to hereditary cancer testing.

Purpose of the Study:

  • To assess the efficiency of a population-based genetic testing program for hereditary breast cancer in Poland.
  • To evaluate the cost-effectiveness of identifying BRCA1 mutations through public outreach.
  • To determine compliance with screening recommendations among identified mutation carriers.

Main Methods:

  • 5024 Polish women were offered free genetic testing for common BRCA1 founder mutations after a magazine announcement.

Related Experiment Videos

  • Genetic counseling was provided to positive cases and those with significant family histories.
  • Mutation detection cost and screening compliance were analyzed one year post-testing.

    • Main Results:

    • 198 women (3.9%) carried a BRCA1 mutation.
    • The cost per mutation detected was significantly lower than in North America ($630 USD).
    • Two-thirds of identified mutation carriers adhered to recommended breast cancer screening after one year.

    Conclusions:

    • A public outreach model for genetic testing is highly efficient in populations with predominant founder mutations.
    • This approach effectively increases access to genetic testing and promotes adherence to cancer screening.
    • Further studies are warranted to validate this model in diverse populations.