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Updated: Aug 7, 2026
An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
Published on: June 24, 2025
Colonization of the medial lumen is a risk factor for catheter-related bloodstream infection
Josep-Maria Sirvent1, Loreto Vidaur, María García
1Department of Intensive Care, Hospital Universitari de Girona Doctor Josep Trueta, Avda. de França s/n, 17007, Girona, Spain. uci.jmsirvent@htrueta.scs.es
Objective:
To analyze the colonization of each lumen and the risk factors for triple-lumen central venous catheter-related bloodstream infection (CRBI).
Design And Setting:
Prospective, observational study in the medical-surgical intensive care unit (ICU) of a teaching hospital.
Patients:
A total of 120 patients requiring the insertion of a triple-lumen catheter.
Interventions:
Cultures of the catheter.
Measurements And Results:
The catheters were removed when CRBI was suspected or at discharge from ICU. At the removal time, blood cultures, a swab of the insertion site and a culture of the catheter tip were performed. Furthermore, we made quantitative cultures of the proximal, medial and distal lumen. We diagnosed CRBI in six patients (3.35 CRBI/1,000 days at risk), and we observed that in these patients colonization of the medial lumen was more frequent (5/6) than in patients without CRBI (9/114; p = 0.0001). The logistic regression analysis showed that colonization of the medial lumen was an independent risk factor for CRBI (OR 28.1, 95% CI 2.2-364.9).
Conclusions:
Colonization of the medial lumen is an independent risk factor for triple-lumen catheter-related bloodstream infection, possibly due to the absence of use of this lumen.
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