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Pseudomonas aeruginosa sepsis in stem cell transplantation patients

Rosa Fanci1, Patrizia Pecile, Enrico Casalone

  • 1Department of Hematology, Careggi Hospital, Firenze, Italy. rfanci@unifi.it

Infection Control and Hospital Epidemiology
|June 30, 2006
PubMed

Insights

A Pseudomonas aeruginosa outbreak in a bone marrow unit was investigated. Environmental and patient samples revealed a single source for the bacterial infections.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Microbiology

Background:

  • Bone marrow transplantation units are susceptible to healthcare-associated infections.
  • Pseudomonas aeruginosa is an opportunistic pathogen frequently implicated in hospital-acquired infections.

Purpose of the Study:

  • To investigate the source and transmission of a Pseudomonas aeruginosa outbreak.
  • To identify the common source of infection in a bone marrow transplantation unit.

Main Methods:

  • Epidemiological investigation of 6 patient cases.
  • Phenotypic analysis of Pseudomonas aeruginosa isolates.
  • Molecular analysis of patient and environmental isolates.

Main Results:

  • Identified 6 patients with Pseudomonas aeruginosa infection.
  • Confirmed shared room usage among infected patients.
  • Linked patient isolates to a common environmental source through phenotypic and molecular analyses.

Conclusions:

  • A single environmental source was the likely origin of the Pseudomonas aeruginosa outbreak.
  • Environmental contamination poses a significant risk in immunocompromised patient settings.
  • Strict environmental monitoring and control are crucial in bone marrow transplantation units.

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