Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Childhood multiple sclerosis: a review.

Amy Waldman1, Erin O'Connor, Gihan Tennekoon

  • 1Department of Neurology, Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Mental Retardation and Developmental Disabilities Research Reviews
|June 30, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors Influencing Early and Late B-Cell Repopulation After Rituximab Therapy in Pediatric Central Nervous System Inflammatory Disorders.

Pediatric neurology·2026
Same author

Telomere length as a marker of biological age in paediatric multiple sclerosis.

Journal of neurology, neurosurgery, and psychiatry·2026
Same author

Characteristics of Study Design and Statistical Analysis in OCT-Based Studies of Neurodegeneration.

Ophthalmology science·2025
Same author

A Team-Based Partner-Driven Model for Delivering Outpatient Exposure Treatment for Pediatric Anxiety and Obsessive-Compulsive Disorder.

JAACAP open·2025
Same author

Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2025
Same author

Bi-allelic variants in BCAT1 impair mitochondrial function and are associated with a candidate neurometabolic disorder.

HGG advances·2025
Same journal

Conceptualization and measurement of family outcomes associated with families of individuals with intellectual disabilities.

Mental retardation and developmental disabilities research reviews·2007
Same journal

Meta-analysis of family-centered helpgiving practices research.

Mental retardation and developmental disabilities research reviews·2007
Same journal

Maternal depression and developmental disability: research critique.

Mental retardation and developmental disabilities research reviews·2007
Same journal

Expressed emotion in families of children and adults with intellectual disabilities.

Mental retardation and developmental disabilities research reviews·2007
Same journal

Family adaptation to intellectual and developmental disabilities.

Mental retardation and developmental disabilities research reviews·2007
Same journal

Sociocultural studies of families of children with intellectual disabilities.

Mental retardation and developmental disabilities research reviews·2007
See all related articles

Childhood multiple sclerosis (MS) shares symptoms with adult MS but often presents as a single symptom. Further research is needed on its course, causes, and treatment in children.

Area of Science:

  • Neurology
  • Immunology
  • Pediatrics

Background:

  • Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS).
  • Pediatric MS is increasingly recognized, presenting similar symptoms to adult MS, including visual, sensory, and motor deficits.
  • Diagnosis in children often relies on cerebrospinal fluid (CSF) analysis and MRI, though lesion counts may be lower than in adults.

Purpose of the Study:

  • To review the current understanding of pediatric multiple sclerosis.
  • To highlight diagnostic criteria and challenges in childhood MS.
  • To discuss the current status of disease-modifying therapies in pediatric MS.

Main Methods:

  • Review of existing literature on pediatric multiple sclerosis.

Related Experiment Videos

  • Analysis of diagnostic criteria, including revised McDonald criteria.
  • Examination of safety and tolerability data for disease-modifying therapies in children.

    • Main Results:

    • Pediatric MS patients exhibit symptoms like weakness, spasticity, and ataxia, alongside sensory and visual complaints.
    • Diagnostic tools include CSF analysis for immunoglobulins and oligoclonal bands, and MRI for white matter lesions.
    • Children are more prone to monosymptomatic presentations, complicating diagnosis.
    • While some adult MS therapies show safety in children, none are specifically approved for pediatric use.

    Conclusions:

    • Pediatric MS shares clinical and diagnostic features with adult MS but may have a different clinical course.
    • Earlier diagnosis is possible with revised criteria, but the higher incidence of monosymptomatic illness in children presents a challenge.
    • Further investigation into the pathogenesis, clinical course, and optimal treatment of childhood-onset MS is essential.