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Related Experiment Videos

Atm haploinsufficiency does not affect ionizing radiation mutagenesis in solid mouse tissues.

Lanelle Connolly1, Michael Lasarev, Robert Jordan

  • 1Center for Research on Occupational and Environmental Toxicology (CROET), Oregon Health and Sciences University, Portland, OR 97239, USA.

Radiation Research
|July 1, 2006
PubMed
Summary

Partial loss of ATM gene function (Atm haploinsufficiency) in mice did not increase radiation-induced mutations or affect cell viability in solid tissues. This suggests haploinsufficiency does not enhance mutagenic response to radiation.

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Area of Science:

  • Genetics
  • Radiation Biology
  • Cancer Research

Background:

  • Ataxia telangiectasia (AT) is an autosomal recessive disorder caused by mutations in the ATM gene.
  • Individuals with AT exhibit extreme radiation sensitivity and a high cancer predisposition.
  • ATM carriers (heterozygotes) may have a modest increase in cancer risk and radiation sensitivity, but the extent is unclear.

Purpose of the Study:

  • To investigate if partial loss of ATM function (Atm haploinsufficiency) increases the mutagenic response in solid tissues after radiation exposure.
  • To determine the effect of Atm haploinsufficiency on cellular viability following radiation exposure.

Main Methods:

  • Utilized a mouse model of Atm haploinsufficiency.
  • Exposed mice to ionizing radiation.

Related Experiment Videos

  • Assessed mutations in the autosomal mouse Aprt gene in kidney and ear tissues.
  • Compared results with wild-type Atm mice from a previous study.

    • Main Results:

    • Radiation readily induced autosomal mutations in both kidney and ear tissues.
    • Atm haploinsufficiency did not alter the radiation mutagenic response in either tissue.
    • No effect of Atm haploinsufficiency on reduced cellular viability due to radiation exposure was observed.

    Conclusions:

    • Atm haploinsufficiency does not enhance the mutagenic response to radiation in quiescent cells of mouse solid tissues.
    • Partial loss of ATM function does not decrease cellular viability following radiation exposure in these tissues.