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Related Experiment Videos

Aneurysmal bone cysts express vascular markers.

Anjali Shinde1, Charles T Mehlman, Margaret H Collins

  • 1Division of Pathology and Laboratory Medicine, ML1010, B4.180, University of Cincinnati Children's Hospital Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|July 1, 2006
PubMed
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Aneurysmal bone cysts (ABCs) may involve vascular abnormalities. Studies suggest the cystic spaces in ABCs are linked to blood vessels, supporting the theory of vascular injury in their development.

Area of Science:

  • Orthopedics
  • Vascular Biology
  • Pathology

Background:

  • Clonal chromosome abnormalities are found in aneurysmal bone cyst (ABC) mural spindle cells.
  • The nature of the cystic spaces within ABCs remains unclear.
  • Endothelial injury is a proposed mechanism for aneurysmal formation in ABCs, yet vascular markers are understudied.

Purpose of the Study:

  • To investigate the relationship between ABC cavities and vasculature.
  • To survey vascular markers in primary aneurysmal bone cysts.

Main Methods:

  • Immunohistochemical staining of 25 primary ABCs using various vascular antibodies.
  • Analysis of antibody staining patterns at the edge of ABC cavities.

Main Results:

Related Experiment Videos

  • Factor 8 antibody stained the edge of ABC cavities in nearly all cases.
  • Antibodies to VEGF-C, GLUT-1, and smooth muscle actin showed positive staining in about half of the cases.
  • D2-40 and CD34 antibodies also stained the cavity edges in some instances.

Conclusions:

  • The results indicate that ABC cavities are associated with vasculature.
  • These findings support the hypothesis that vascular injury plays a role in the pathogenesis of ABCs.