Differential effects of psychoactive drugs in adolescents and adults

Sari Izenwasser1

  • 1Department of Psychiatry and Behavioral Sciences, University of Miami, School of Medicine, Miami, FL 33136, USA. s.izenwasser@miami.edu

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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