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Updated: Aug 7, 2026
09:36
Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Hyaluronan in human acute and chronic dermal wounds
Tracey A Dechert1, Ashley E Ducale, Susan I Ward
1Department of Surgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA.
Summary
This study found that pressure ulcers have higher inflammation and lower hyaluronan levels compared to normal healing wounds. Increased hyaluronidase activity may degrade hyaluronan during wound repair.
Area of Science:
- Biochemistry
- Dermatology
- Wound Healing Research
Background:
- Hyaluronan plays a role in physiological processes, including wound healing.
- Understanding the relationship between hyaluronan and inflammation is crucial for wound repair research.
Purpose of the Study:
- To quantitatively compare inflammation and hyaluronan expression in human normal healing open wounds versus pressure ulcers.
- To investigate the role of hyaluronidase activity in the degradation of hyaluronan during wound repair.
Main Methods:
- Utilized an open dermal wound model in humans.
- Measured myeloperoxidase activity as an indicator of inflammation.
- Quantified hyaluronan levels and hyaluronidase activity.
Main Results:
- Myeloperoxidase activity peaked at day 3 in acute wounds.
- Hyaluronan levels exhibited a bimodal distribution in acute wounds (peaks on days 1 and 7).
- Pressure ulcers showed significantly higher myeloperoxidase activity and significantly lower hyaluronan levels compared to acute wounds.
- Hyaluronidase activity was significantly elevated in pressure ulcers.
Conclusions:
- Suggests a role for increased enzymatic degradation of hyaluronan due to inflammation in wound repair.
- Highlights the first quantitative examination of hyaluronan expression in human acute dermal wounds and chronic pressure ulcers.
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