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Ameliorating human diabetic neuropathy: lessons from implanting hematopoietic mononuclear cells

R A Malik1, A Veves, S Tesfaye

  • 1Division of Cardiovascular and Endocrine Sciences, University of Manchester, Manchester, UK. Rayaz.a.malik@man.ac.uk

Experimental Neurology
|July 1, 2006
PubMed
Abstract

No abstract available in PubMed .

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...