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Updated: Aug 7, 2026
Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice
Published on: June 13, 2012
Novel object recognition in Apoe(-/-) mice improved by neonatal implantation of wild-type multipotential stromal
Alexandra Peister1, Suzanne Zeitouni, Timothy Pfankuch
1Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
Abstract:
Multipotential bone marrow stromal cells (MSCs) from wild-type (Wt) or apolipoprotein E deficient (Apoe(-/-)) mice were implanted into the cerebral ventricles of Apoe(-/-) mice. MSCs from Wt mice continued expressing apoE up to 6 months after implantation and were associated with enhanced novel object recognition and increased microtubule-associated protein 2 (MAP2) immunoreactivity in the dentate gyrus. These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases.
