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IdeR in mycobacteria: from target recognition to physiological function
Sarita Ranjan1, Sailu Yellaboina, Akash Ranjan
1Sun Centre of Excellence in Medical Bioinformatics, Centre for DNA Fingerprinting and Diagnostics, EMBnet India Node, Hyderabad 500076, India.
Critical Reviews in Microbiology
|July 1, 2006
Summary
The iron-dependent regulator (IdeR) controls gene expression in mycobacteria based on iron availability. This review synthesizes current knowledge on IdeR and its targets, clarifying its role in mycobacterial physiology.
Area of Science:
- Microbiology
- Molecular Biology
- Genetics
Background:
- The iron-dependent transcription regulator (IdeR) is crucial for managing gene expression in response to iron levels within mycobacteria.
- Research on IdeR-regulated genes has primarily focused on species like Mycobacterium tuberculosis and Mycobacterium smegmatis.
Purpose of the Study:
- To consolidate current understanding of IdeR and its identified targets.
- To elucidate the regulatory design of the IdeR regulon.
- To explore the physiological significance of IdeR in mycobacteria.
Main Methods:
- Review of existing literature on IdeR.
- Analysis of crystal structure data for IdeR.
- Compilation of computational and experimental findings on IdeR targets.
Main Results:
- Recent advancements in structural biology and target identification have deepened insights into IdeR's function.
- A comprehensive overview of known IdeR-regulated genes across various mycobacterial species is presented.
Conclusions:
- The IdeR regulon exhibits a defined design, crucial for adapting to iron availability.
- IdeR plays a significant role in regulating essential mycobacterial physiological processes.