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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
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Published on: April 9, 2014

Hypersusceptibility to substrate analogs conferred by mutations in human immunodeficiency virus type 1 reverse

Robert A Smith1, Donovan J Anderson, Bradley D Preston

  • 1Department of Pathology, University of Washington, K-084 HSB, Box 357705, 1959 NE Pacific St., Seattle, 98195, USA. smithra@u.washington.edu

Journal of Virology
|July 1, 2006
PubMed
Summary

Mutations in HIV-1 reverse transcriptase motif B alter drug sensitivity. Specific changes confer broad resistance or hypersusceptibility to nucleoside and pyrophosphate analogs, impacting HIV-1 treatment strategies.

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