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Treatment of iron deficiency anemia with intravenous iron preparations

Saadet Akarsu1, Erdal Taskin, Erdal Yilmaz

  • 1Department of Pediatrics, Medical Faculty of Firat University, Elazig, Turkey. aksaadet@yahoo.com

Acta Haematologica
|July 1, 2006
PubMed

Insights

Intravenous iron therapy effectively improves blood parameters in pediatric patients with iron deficiency anemia who cannot tolerate oral iron. This method offers rapid improvement and is well-tolerated, though oral supplementation may be needed.

Area of Science:

  • Pediatric Hematology
  • Clinical Nutrition
  • Pharmacology

Background:

  • Iron deficiency anemia (IDA) is common in children.
  • Oral iron therapy is the first-line treatment but adherence and efficacy can be limited.
  • Alternative strategies are needed for rapid hemoglobin normalization, especially in surgical candidates.

Purpose of the Study:

  • To evaluate the efficacy and safety of intravenous iron sucrose in pediatric patients with IDA.
  • To assess the impact on key hematological and iron metabolism parameters.
  • To compare outcomes in patients intolerant to oral iron.

Main Methods:

  • A prospective study involving 62 pediatric patients requiring rapid hemoglobin increase.
  • Intravenous iron sucrose administered to patients intolerant to oral iron.
  • Blood samples analyzed for hemoglobin, hematocrit, erythrocyte indices, serum iron, iron binding capacity, transferrin receptor (CD71), and serum ferritin at baseline and multiple follow-up points (1 week, 1, 2, 3 months).

Main Results:

  • Significant improvements in most blood parameters were observed within 1 week of intravenous iron therapy.
  • Serum iron levels increased up to 1 month post-treatment.
  • Transferrin receptor levels showed no significant change post-therapy.
  • Serum ferritin levels peaked at 1 month and did not exceed this value.
  • Mild side effects occurred in 12.9% of patients, with no treatment discontinuations.

Conclusions:

  • Intravenous iron therapy is a safe and effective alternative for pediatric IDA patients with poor oral iron tolerance or need for rapid hematological improvement.
  • It can be a valuable option for pre-operative anemia management.
  • Consideration for oral iron reinforcement or additional intravenous doses may be beneficial for sustained correction.
Abstract

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