Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ectopic ACTH syndrome.

Andrea M Isidori1, Gregory A Kaltsas, Ashley B Grossman

  • 1DFM, Department of Pathophysiology, University 'La Sapienza' of Rome, Rome, Italy.

Frontiers of Hormone Research
|July 1, 2006
PubMed
Summary

Ectopic adrenocorticotropin secretion (EAS) causes Cushing's syndrome. Identifying the source is crucial for treatment, though it remains occult in 10-20% of cases, requiring medical management or adrenalectomy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal changes in cortisol secretion and their association with long-term outcomes in benign adrenal incidentalomas: a retrospective cohort study.

The lancet. Diabetes & endocrinology·2026
Same author

Molecular Dynamics Analysis of the Stereoselective Recognition of Myo-Inositol and D-Chiro-Inositol in a Protein-Based Biosensor.

Sensors (Basel, Switzerland)·2026
Same author

Rethinking hypercortisolism screening in obesity and diabetes: A systematic review and meta-analysis.

Metabolism: clinical and experimental·2026
Same author

Management of gynecomastia in adolescence and adults: the clinical practice guidelines from the Italian Society of Andrology and Sexual Medicine (SIAMS).

Journal of endocrinological investigation·2026
Same author

Sleeve Gastrectomy in Paediatric and Transition Age Patients with Prader-Willi Syndrome: A 5-Year Longitudinal Study.

The Journal of clinical endocrinology and metabolism·2026
Same author

Sex differences in classic congenital adrenal hyperplasia: a multicenter, real-world analysis.

Frontiers in endocrinology·2026

Area of Science:

  • Endocrinology
  • Oncology

Background:

  • Ectopic adrenocorticotropin secretion (EAS) causes Cushing's syndrome, presenting diverse tumors and severe hypercortisolism.
  • Associated symptoms include hypokalemia, diabetes, infections, hypertension, and psychosis.

Purpose of the Study:

  • To review clinical features, diagnostic challenges, management strategies, and long-term outcomes of EAS.
  • To emphasize the importance of localizing ectopic ACTH sources for optimal patient care.

Main Methods:

  • Review of clinical data from major referral centers focusing on EAS.
  • Analysis of diagnostic modalities including cross-sectional imaging.
  • Evaluation of treatment outcomes for surgical and medical interventions.

Main Results:

  • Surgical resection is curative in up to 80% of cases where the primary lesion is identified (approx. 40% of patients).
  • Cross-sectional imaging identifies most ACTH-secreting lesions.
  • In 10-20% of EAS cases, the source remains occult, necessitating long-term medical management or bilateral adrenalectomy.

Conclusions:

  • Accurate localization of ectopic ACTH sources is essential for effective management of Cushing's syndrome.
  • While imaging is effective, a significant proportion of EAS cases require alternative management strategies.
  • Long-term follow-up and tailored treatment approaches are critical for patients with EAS.

Related Experiment Videos