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Updated: Aug 7, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology
Published on: May 22, 2026
Therapeutic alliance mediates the relationship between interpersonal problems and depression outcome in a cohort of
Isa Howard1, Rebecca Turner, Rhoda Olkin
1San Francisco Veteran's Affairs Medical Center, San Francisco, CA 94131, USA. Isa.Howard@va.gov
Abstract:
The relationship among therapeutic alliance, psychotherapy outcomes, and interpersonal problems was examined. The present study hypothesized therapeutic alliance would mediate the relationship between interpersonal functioning and outcome among patients with multiple sclerosis entering psychotherapy for depression. Nineteen clients received 16 weeks of individual cognitive-behavioral therapy (CBT) for depression as described by D. C. Mohr, A. C. Boudewyn, D. E. Goodkin, A. Bostrom, and L. Epstein (2001). Participants completed the Beck Depression Inventory (BDI; Beck, Ward, Mendelson, Mock, & Erbaugh, 1961), the Inventory of Interpersonal Problems-Circumplex (IIP-C; Alden, Wiggins, & Pincus, 1990), and the Working Alliance Inventory-Client Form (WAI-C; Horvath & Greenberg, 1989). The IIP-C significantly predicted Week 16 BDI and the WAI-C at 4 weeks. When controlling for the WAI-C, the relationship between the IIP-C and BDI was no longer significant, supporting the mediational hypothesis.
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