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The diagnostic value of faecal trypsin estimation in chronic pancreatic disease

G K McGowan1, M R Wills

  • 1Department of Pathology, United Bristol Hospitals.

Journal of Clinical Pathology
|January 1, 1962
PubMed

Insights

Faecal trypsin testing is not specific for pancreatic dysfunction but can help screen for severe pancreatic disease. This aids in selecting patients for further, more specific investigations.

Area of Science:

  • Clinical Chemistry
  • Gastroenterology
  • Pediatrics

Background:

  • Pancreatic dysfunction requires accurate diagnostic methods.
  • Screening tests are valuable for identifying patients needing further investigation.

Purpose of the Study:

  • To evaluate faecal trypsin levels as a screening tool for pancreatic disease.
  • To assess the specificity and utility of faecal trypsin testing.

Main Methods:

  • Photometric azo-casein method used to estimate faecal trypsin.
  • Study included 242 children and 45 adults.

Main Results:

  • Faecal trypsin levels were measured in a cohort of children and adults.
  • The test demonstrated utility as a screening method rather than a specific diagnostic one.

Conclusions:

  • Faecal trypsin testing is a useful preliminary screen for severe pancreatic disease.
  • It helps identify patients who warrant more in-depth pancreatic function tests.

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