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Updated: Aug 7, 2026

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
Published on: June 22, 2015
Positive contrast, negative induction, and inhibitory stimulus control in the rat
Abstract:
In Experiment I, 24 rats were trained on a multiple variable-interval variable-interval schedule with a doorlight and white noise serving as component cues. Two groups were then shifted to a multiple extinction variable-interval schedule, and a third group was maintained on the multiple variable-interval variable-interval schedule. The multiple extinction variable-interval condition produced positive contrast when either the light or noise signalled extinction, and both of these cues acquired inhibitory stimulus control as measured by a combined cue test. In Experiment II, the multiple variable-interval variable-interval condition was shifted to multiple extinction variable-interval for one group, to multiple variable-time variable-interval for a second group, and was unchanged for the third group. The two experimental conditions produced identical patterns of response-rate reduction in the altered component, but the multiple extinction variable-interval condition produced positive contrast, whereas the multiple variable-time variable-interval condition did not. Subsequent combined cue and resistance to reinforcement tests revealed that the cue signalling extinction acquired stronger inhibitory stimulus control than the cue signalling variable time.

